Antitheta-sensitive regulatory cell (TSRC) and hematopoiesis: regulation of differentiation of transplanted stem cells in W/Wv anemic and normal mice.

@article{Sharkis1978AntithetasensitiveRC,
  title={Antitheta-sensitive regulatory cell (TSRC) and hematopoiesis: regulation of differentiation of transplanted stem cells in W/Wv anemic and normal mice.},
  author={Saul J. Sharkis and Wieslaw Wiktor-Jedrzejczak and Aftab Ahmed and George W. Santos and Andy McKee and Kenneth W. Sell},
  journal={Blood},
  year={1978},
  volume={52 4},
  pages={802-17}
}
The macrocytic anemia of the W/W mouse can be cured by the injection of normal littermate bone marrow cells into nonirradiated recipients. In addition to the stem cell requirement for this cure, we describe a cell type sensitive to treatment in vitro with antitheta serum and complement that appeared to be required for a cure. The mechanism of action of this antitheta-sensitive regulatory cell (TSRC) involves its effect on the pluripotent stem cell. Cells from the thymus of normal littermates… CONTINUE READING
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