Antispermatogenic Activity of the Benzothiazoline Ligand and Corresponding Organoantimony(V) Derivative in Male Albino Rats

@article{Sharma2006AntispermatogenicAO,
  title={Antispermatogenic Activity of the Benzothiazoline
Ligand and Corresponding Organoantimony(V) Derivative in Male Albino Rats},
  author={Pankaj Kumar Sharma and H. Rehwani and Audhesh K. Rai and Rajnish Gupta and Y. Premkumar Singh},
  journal={Bioinorganic chemistry and applications},
  year={2006},
  volume={2006},
  pages={301 - 308}
}
Triphenylantimony(V) derivative, Ph(3)Sb(OPr(i)) [SC(6)H(4)N : C(CH(3))CH(2)C(O)CH(3)], 1b, and the corresponding benzothiazoline ligand [1, 2], HNC(6)H(4)SC(CH(3))CH(2)C(O)CH(3), 1a, have been tested for their effects on the reproductive system of male albino rats. The oral administration of both 1a and 1b at the dose level of 10 mg/rat/day produced significant reduction in the weights of testes, epididymides, seminal vesicles, and ventral prostate. Significant decrease in sperm motility as… CONTINUE READING