Antispasmodic activity of benzylisoquinoline alkaloids analogous to papaverine.

  title={Antispasmodic activity of benzylisoquinoline alkaloids analogous to papaverine.},
  author={Mar{\'i}a Luisa Mart{\'i}n and Mar{\'i}a Teresa Sanz D{\'i}az and Mar{\'i}a Jos{\'e} Montero and Pilar Prieto and Luis San Rom{\'a}n and Diego Cort{\'e}s},
  journal={Planta medica},
  volume={59 1},
In vitro, reticuline, norarmepavine, coclaurine, and papaverine competitively antagonize the uterine muscular contractions induced by acetylcholine and calcium. The antagonism is more efficient for the alkaloid coclaurine which is even stronger than papaverine. The pA2 values obtained with each of the four alkaloids for both agents, acetylcholine and calcium, respectively, were as follows: reticuline (5.35 and 4.81), norarmepavine (5.55 and 4.09), coclaurine (7.42 and 6.91), papaverine (5.32… CONTINUE READING