Antiserum to activity-dependent neurotrophic factor produces neuronal cell death in CNS cultures: immunological and biological specificity.

@article{Gozes1997AntiserumTA,
  title={Antiserum to activity-dependent neurotrophic factor produces neuronal cell death in CNS cultures: immunological and biological specificity.},
  author={Illana Gozes and Alec J. Davidson and Yehoshua Gozes and R Mascolo and RichardJ. Barth and Doug Warren and Janet Hauser and Douglas E. Brenneman},
  journal={Brain research. Developmental brain research},
  year={1997},
  volume={99 2},
  pages={167-75}
}
Activity-dependent neurotrophic factor (ADNF) is a glia-derived protein that is neuroprotective at femtomolar concentrations. ADNF is released from astroglia after treatment with 0.1 nM vasoactive intestinal peptide (VIP). To further assess the biological role of ADNF, antiserum was produced following sequential injections of purified ADNF into mice. Anti-ADNF ascites fluid (1:10,000) decreased neuronal survival by 45-55% in comparison to untreated cultures or those treated with control ascites… CONTINUE READING

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