• Corpus ID: 82568633

Antiserum Neutralization of Bacteriophage Q β: A Mathematical Analysis

  title={Antiserum Neutralization of Bacteriophage Q $\beta$: A Mathematical Analysis},
  author={E. M. Hale and ARTHUR A. Hirata and R. A. Brusenback and Lacy R. Overby},
  journal={Journal of Immunology},
Summary The inactivation of the bacteriophage, Q β, with specific antiserum was studied. The reaction exhibited a continual decrease in rate that was evident from the beginning. The same limiting value of the surviving fraction was reached by all concentrations of a serum. The deviation from first order kinetics was not attributable to dissociation or pre-existing phage heterogenity. The results support the idea of the development of resistant phages by interaction with antiserum components… 
Interaction of Viruses with Neutralizing Antibodies
Possibly the earliest published expectation and demonstration of the neutralizing capacity of humoral antibody is contained in the report of Sternberg (1892), which demonstrated that the serum of a calf recently vaccinated with cowpox (?) virus neutralized the infectivity of this virus when the two were mixed prior to inoculation.
Neutralization of Animal Viruses
  • B. Mandel
  • Biology
    Advances in Virus Research
  • 1978
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