Antiseptics and Disinfectants: Activity, Action, and Resistance

@article{Mcdonnell1999AntisepticsAD,
  title={Antiseptics and Disinfectants: Activity, Action, and Resistance},
  author={Gerald E. Mcdonnell and A. Denver Russell},
  journal={Clinical Microbiology Reviews},
  year={1999},
  volume={12},
  pages={147 - 179}
}
SUMMARY Antiseptics and disinfectants are extensively used in hospitals and other health care settings for a variety of topical and hard-surface applications. A wide variety of active chemical agents (biocides) are found in these products, many of which have been used for hundreds of years, including alcohols, phenols, iodine, and chlorine. Most of these active agents demonstrate broad-spectrum antimicrobial activity; however, little is known about the mode of action of these agents in… Expand
Common Antiseptics : Mechanism Of Action And Its Uses In Animal
Antiseptics are extensively used in Hospital and other health care setting for a variety of topical applications. In particular antiseptics are essential part of infection control practice and aid inExpand
Mechanisms of antimicrobial action of antiseptics and disinfectants: an increasingly important area of investigation.
  • A. D. Russell
  • Biology, Medicine
  • The Journal of antimicrobial chemotherapy
  • 2002
TLDR
The term ‘biocide’ is increasingly being used to describe compounds with antiseptic, disinfectant or, sometimes, preservative activity, and early studies on the action of such compounds concentrated on the kinetics of bacterial inactivation. Expand
New Generation Disinfectants
TLDR
A wide range of chemical agents like alcohols, chlorine compounds, gluteraldehyde, iodophors, phenolics has been used for long years but most of them demonstrate broad-spectrum antimicrobial activity at higher concentrations and also can cause environmental problems at these concentrations. Expand
Cationic antiseptics: diversity of action under a common epithet
TLDR
Action mechanisms for cationic antimicrobials are examined and key differences that render them distinct categories of antibacterial agent are highlighted that have profound implications in terms of cross-resistance. Expand
Topical Antiseptics in Healthcare
  • M. Jackson
  • Medicine
  • American Society for Clinical Laboratory Science
  • 2005
TLDR
This article explores currently available topical antimicrobial agents used in medical settings with a focus on antiseptics for hand washing, surgical scrubbing, and patient preoperative skin preparation. Expand
STRUCTURE AND PHYSICOCHEMICAL PROPERTIES OF ANTISEPTICS AND DISINFECTANTS IN RELATION TO THEIR ACTIVITY
Antiseptics and disinfectants represent a large group of compounds that have different effects depending on the used concentration. They are substances that remove bacteria from the skin or materialsExpand
Current and Emerging Topical Antibacterials and Antiseptics: Agents, Action, and Resistance Patterns
TLDR
A comprehensive understanding of the clinical efficacy and drivers of resistance to topical agents will inform the optimal use of these agents to preserve their activity in the future. Expand
Modes of action of three disinfectant active substances: a review.
This review deals with three categories of active substances for disinfectant products, their modes of action (MOA), and how MOA can help predict propensity for resistance in microorganisms. WithinExpand
Sterilization and Disinfection
TLDR
A much wider range of antimicrobial chemicals are used for various microbicidal and/or preservative applications, including types of alcohols, aldehydes, halogens, antimicrobial metals, and phenolics. Expand
Decontamination, Disinfection, and Sterilization
TLDR
It is observed that on average 0.2 mg of protein remains on surgical instruments despite “standard cleaning and disinfection,” which was sufficient to cause an experimental case of CJD, therefore, more research and new methods of cleaning andinfection are needed for surgical instruments. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 698 REFERENCES
The effects of antiseptics, disinfectants and preservatives on smooth, rough and deep rough strains of Salmonella typhimurium
The effects of some antiseptics, disinfectants and preservatives on a smooth strain and rough mutant strains (Ra, Rd1 and Re) of Salmonella typhimurium are described. The inhibitors consisted ofExpand
Resistance mechanisms of mucoid-grown Staphylococcus aureus to the antibacterial action of some disinfectants and antiseptics
TLDR
The effects of commercial preparations of some disinfectants and antiseptics on mucoid-grown Staphylococcus aureus were investigated and reductions in antibacterial efficacies were comparable to the inhibitory effects of hard water, killed yeast, asparagine, blood plasma, thioglycollate and Tween-80. Expand
Handbook of disinfectants and antiseptics.
TLDR
This work presents a broad-based approach to evaluating topical antiseptics and disinfectants neutralizer evaluations as control experiments for antimicrobial efficacy studies in dentistry contact lens disinfectants. Expand
Comparative susceptibility of hospital isolates of gram-negative bacteria to antiseptics and disinfectants.
TLDR
The sensitivity of hospital isolates of Gram-negative bacteria to cationic antiseptics, mercuric chloride and two organomercury compounds has been measured and all strains of Escherichia coli showed a uniformly high sensitivity to chlorhexidine diacetate. Expand
BACTERIAL RESISTANCE TO QUATERNARY AMMONIUM DISINFECTANTS
  • C. Chaplin
  • Biology, Medicine
  • Journal of bacteriology
  • 1952
TLDR
During the course of developing the resistant strain with the most rapid increase of resistance, it was shown that this is not acquired in an orderly manner. Expand
In vitro susceptibility of hospital isolates of various bacterial genera to chlorhexidine.
TLDR
The MIC and minimum bactericidal concentration (MBC) of chlorhexidine are investigated against a wide range of bacterial genera, in particular those bacteria which are most frequently isolated from hospitalacquired infections (Meers et al., 1981). Expand
Multidrug resistance to antiseptics and disinfectants in coagulase-negative staphylococci.
TLDR
Resistance to antiseptics and disinfectants in clinical isolates of coagulase-negative staphylococci was examined and it was revealed that this resistance was mediated by the multidrug export genes qacA and qacC, characterised previously in S. aureus. Expand
Laboratory and in-vitro testing of skin antiseptics: a prediction for in-vivo activity?
TLDR
In-vitro tests aimed at duplicating natural conditions (including the effect of antiseptics on bacterial biofilms, or better, on the different infective units) are under evaluation, and tests involving natural skin surfaces, like the Story test, offer reproducible and useful data. Expand
Safety and efficacy of the antiseptic chlorhexidine gluconate.
TLDR
Hibiclens, Hibitane tinted tincture and 0.5 per cent aqueous chlorhexidine gluconate were shown to have an extremely low potential for the production of irritation, allergic contact sensitization, photoallergic contact sensitized and phototoxicity, and to be a fast acting, broad spectrum antimicrobial agent. Expand
Sensitivity of the genus Proteus to chlorhexidine.
  • T. Martin
  • Biology, Medicine
  • Journal of medical microbiology
  • 1969
TLDR
The action of the antiseptic chlorhexidine has been tested against 205 strains of the genus Proteus and, in general, Pr. Expand
...
1
2
3
4
5
...