Antisense transcripts of V(D)J rearrangements; artifacts caused by false priming?

@article{Zhao2009AntisenseTO,
  title={Antisense transcripts of V(D)J rearrangements; artifacts caused by false priming?},
  author={Yuan Zhao and Deborah K. Dunn-Walters and F Barone and Jo Spencer},
  journal={Molecular immunology},
  year={2009},
  volume={46 11-12},
  pages={
          2357-62
        }
}
Somatic hypermutation (SH) of V(D)J rearrangements at the IGH and IGL loci diversifies the IG repertoire during the germinal center response. SH is absolutely dependent on the enzyme activation induced cytidine deaminase (AID) that initiates the SH process by deaminating C nucleotides in ssDNA. Mutations from G and C are thought to occur as a result of strand symmetrical deamination of C by AID on the coding and non-coding strands respectively. Mutations from A and T are introduced in a strand… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 15 REFERENCES

Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2008
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Does antisense make sense of AID targeting?

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2008
VIEW 1 EXCERPT