Antisense transcription and heterochromatin at the DM1 CTG repeats are constrained by CTCF.

@article{Cho2005AntisenseTA,
  title={Antisense transcription and heterochromatin at the DM1 CTG repeats are constrained by CTCF.},
  author={Diane H. Cho and Cortlandt Paul Thienes and Sarah E Mahoney and Erwin Analau and Galina N. Filippova and Stephen J. Tapscott},
  journal={Molecular cell},
  year={2005},
  volume={20 3},
  pages={
          483-9
        }
}
Prior studies of the DM1 locus have shown that the CTG repeats are a component of a CTCF-dependent insulator element and that repeat expansion results in conversion of the region to heterochromatin. We now show that the DM1 insulator is maintained in a local heterochromatin context: an antisense transcript emanating from the adjacent SIX5 regulatory region extends into the insulator element and is converted into 21 nucleotide (nt) fragments with associated regional histone H3 lysine 9 (H3-K9… CONTINUE READING
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