Antisense to cyclin D1 inhibits vascular endothelial growth factor-stimulated growth of vascular endothelial cells: implication of tumor vascularization.

@article{Yasui2006AntisenseTC,
  title={Antisense to cyclin D1 inhibits vascular endothelial growth factor-stimulated growth of vascular endothelial cells: implication of tumor vascularization.},
  author={Masayoshi Yasui and Hirofumi Yamamoto and Chew Yee Ngan and Bazarragchaa Damdinsuren and Yurika Sugita and Hiroki Fukunaga and Jinyu Gu and Makiko Maeda and Ichiro Takemasa and Masataka Ikeda and Yasushi Fujio and Mitsugu Sekimoto and Nariaki Matsuura and I. Bernard Weinstein and Morito Monden},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 15},
  pages={
          4720-9
        }
}
PURPOSE Our aim was to determine the effects of cyclin D1 inhibition on tumor-associated neovascularization and endothelial cell growth. EXPERIMENTAL DESIGN We have generated adenovirus system for antisense to cyclin D1 (AS CyD1) and evaluated in vitro and in vivo effects. Small interfering RNA against cyclin D1 was also used to analyze cyclin D1 inhibition-associated vascular endothelial growth factor (VEGF) regulation. RESULTS The xenografts treated with adenoviral AS CyD1 showed less… CONTINUE READING

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