Antisense-thioredoxin inhibits angiogenesis via pVHL-mediated hypoxia-inducible factor-1alpha degradation.

Abstract

Thioredoxin (Trx), a small redox protein, is overexpressed in a number of tumors, however, its roles in tumor cells were not defined well. To investigate the effect of Trx, we transfected Trx or antisense Trx vectors into HT1080 cells. Trx-overexpressed HT1080 cells induced migration of endothelial cells through Flt-1 vascular endothelial growth factor… (More)

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@article{Kim2005AntisensethioredoxinIA, title={Antisense-thioredoxin inhibits angiogenesis via pVHL-mediated hypoxia-inducible factor-1alpha degradation.}, author={Woo Jean Kim and Heeyeong Cho and Sae-Won Lee and Yung-Jin Kim and Kyu-Won Kim}, journal={International journal of oncology}, year={2005}, volume={26 4}, pages={1049-52} }