Antisense telomerase treatment: induction of two distinct pathways, apoptosis and differentiation.

@article{Kondo1998AntisenseTT,
  title={Antisense telomerase treatment: induction of two distinct pathways, apoptosis and differentiation.},
  author={Seiji Kondo and Yoshinori Tanaka and Yasuko Kondo and Masahiro Hitomi and Gene H. Barnett and Yukihito Ishizaka and Jinbo Liu and Talat Haqqi and Ayaka Nishiyama and Bryant Villeponteau and John K Cowell and Barbara P. Barna},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1998},
  volume={12 10},
  pages={801-11}
}
Telomerase, the enzyme that elongates telomeric DNA (TTAGGG)n, may be involved in cellular immortality and oncogenesis. To investigate the effect of inhibition of telomerase on tumor cells, we transfected the antisense vector against the human telomerase RNA into human malignant glioma cells exhibiting telomerase activity. After 30 doublings, some subpopulations of transfectants expressed a high level of interleukin-1beta-converting enzyme (ICE) protein and underwent apoptosis. In contrast… CONTINUE READING

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