Antisense suppression of skeletal muscle myosin light chain-1 biosynthesis impairs myofibrillogenesis in cultured myotubes

@article{Nawrotzki1995AntisenseSO,
  title={Antisense suppression of skeletal muscle myosin light chain-1 biosynthesis impairs myofibrillogenesis in cultured myotubes},
  author={Ralph Nawrotzki and Donald A. Fischman and Takashi Mikawa},
  journal={Journal of Muscle Research & Cell Motility},
  year={1995},
  volume={16},
  pages={45-56}
}
Although the alkali or essential light chains of skeletal muscle myosin are not required for actin-activated myosin ATPase activity, these myosin subunits are necessary for force transmission with in vitro actin motility assays and are believed to stabilize the α-helical neck region of myosin subfragment-1. To probe the functions of the essential light chains during myofibril assembly, we used recombinant DNA procedures to deplete this light chain in cultured muscle. Retroviral expression… CONTINUE READING

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