Antisense suppression of proline-directed protein kinase FA enhances chemosensitivity in human prostate cancer cells.

@article{Yang2000AntisenseSO,
  title={Antisense suppression of proline-directed protein kinase FA enhances chemosensitivity in human prostate cancer cells.},
  author={C. C. Yang and Christopher P Hsu and S D Yang},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2000},
  volume={6 3},
  pages={1024-30}
}
Initial clinic studies revealed that proline-directed protein kinase FA (PDPK FA) is overexpressed manyfold in various human cancerous tissues relative to the normal control. However, the role of overexpressed PDPK FA in cancers remains unknown and needs to be established. To determine whether PDPK FA is associated with drug sensitivity, we investigated the effects of partial inhibition of this kinase on the human prostate carcinoma cell line (PC-3). PDPK FA antisense expression vector and its… CONTINUE READING
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