Antisense phosphorothioate oligodeoxynucleic acid for CD10 suppresses liver metastasis of colorectal cancer.

@article{Luo2009AntisensePO,
  title={Antisense phosphorothioate oligodeoxynucleic acid for CD10 suppresses liver metastasis of colorectal cancer.},
  author={Yi Luo and Kiyomu Fujii and Hitoshi Ohmori and Tomonori Sasahira and Yukiko Moriwaka and Mamoru Isobe and Hiroki Kuniyasu},
  journal={Pathobiology : journal of immunopathology, molecular and cellular biology},
  year={2009},
  volume={76 5},
  pages={267-73}
}
CD10 expression is associated with metastases of colorectal cancer (CRC). In the present study, we examined association of CD10 with liver metastasis of CRC cells to clarify the therapeutic significance of CD10. CD10-positive human colon cancer cell line, HT29 cells showed inhibition of growth, invasion and colony formation by treatment with CD10 antisense S-oligodeoxynucleotide (S-ODN). In the mouse liver metastasis mode, CD10 antisense S-ODN-treated HT29 cells made less embedded cells in the… CONTINUE READING

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