Antisense peptide nucleic acid‐mediated knockdown of the p75 neurotrophin receptor delays motor neuron disease in mutant SOD1 transgenic mice

@article{Turner2003AntisensePN,
  title={Antisense peptide nucleic acid‐mediated knockdown of the p75 neurotrophin receptor delays motor neuron disease in mutant SOD1 transgenic mice},
  author={Bradley J. Turner and Irwin Kee-Mun Cheah and Katherine J Macfarlane and Elizabeth C. Lopes and Steven Petratos and Steven J. Langford and Surinda S Cheema},
  journal={Journal of Neurochemistry},
  year={2003},
  volume={87}
}
Re‐expression of the death‐signalling p75 neurotrophin receptor (p75NTR) is associated with injury and neurodegeneration in the adult nervous system. The induction of p75NTR expression in mature degenerating spinal motor neurons of humans and transgenic mice with amyotrophic lateral sclerosis (ALS) suggests a role of p75NTR in the progression of motor neuron disease (MND). In this study, we designed, synthesized and evaluated novel antisense peptide nucleic acid (PNA) constructs targeting… 
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