Antisense oligonucleotides targeting abhydrolase domain containing 2 block human hepatitis B virus propagation.

@article{Ding2011AntisenseOT,
  title={Antisense oligonucleotides targeting abhydrolase domain containing 2 block human hepatitis B virus propagation.},
  author={Xiaoran Ding and Jing Yang and Shengqi Wang},
  journal={Oligonucleotides},
  year={2011},
  volume={21 2},
  pages={77-84}
}
Hepatitis B virus (HBV) infection is a major health concern worldwide and only a minority of treated patients develop a sustained protective response following a short course of therapy, and most patients require prolonged treatment to suppress viral replication. However, several recent reports showed that inhibition of certain host cell proteins prevented viral infection, specifically the human abhydrolase domain containing 2 (ABHD2) has been confirmed by our previous study to be upregulated… CONTINUE READING

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