Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells.

@article{Machen2004AntisenseOD,
  title={Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells.},
  author={Jennifer Machen and J. B. Harnaha and Robert J Lakomy and Alexis Styche and Massimo Trucco and Nick Giannoukakis},
  journal={Journal of immunology},
  year={2004},
  volume={173 7},
  pages={4331-41}
}
Phenotypically "immature" dendritic cells (DCs), defined by low cell surface CD40, CD80, and CD86 can elicit host immune suppression in allotransplantation and autoimmunity. Herein, we report the most direct means of achieving phenotypic immaturity in NOD bone marrow-derived DCs aiming at preventing diabetes in syngeneic recipients. CD40, CD80, and CD86 cell surface molecules were specifically down-regulated by treating NOD DCs ex vivo with a mixture of antisense oligonucleotides targeting the… CONTINUE READING

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