Antisense oligonucleotide knockdown of mGlu₅ receptor attenuates the antinociceptive tolerance and up-regulated expression of spinal protein kinase C associated with chronic morphine treatment.

Abstract

Spinal metabotropic glutamate receptor 5 (mGlu₅ receptor) is known to influence the development of intrathecal morphine antinociceptive tolerance. However, the signaling mechanisms remain unknown. We carried out intrathecal administration of an antisense oligodeoxynucleotide (ODN), which results in reduced expression of spinal mGlu₅ receptor, to determine… (More)
DOI: 10.1016/j.ejphar.2012.02.046

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@article{Xu2012AntisenseOK, title={Antisense oligonucleotide knockdown of mGlu₅ receptor attenuates the antinociceptive tolerance and up-regulated expression of spinal protein kinase C associated with chronic morphine treatment.}, author={Tao Xu and Moxi Chen and Quanhong Zhou and Ying Xue and Li Wang and Vida J Bil de Arce and Xiaoli Zhang and Wei Jiang}, journal={European journal of pharmacology}, year={2012}, volume={683 1-3}, pages={78-85} }