Antisense oligonucleotide-induced exon skipping restores dystrophin expression in vitro in a canine model of DMD

@article{Mcclorey2006AntisenseOE,
  title={Antisense oligonucleotide-induced exon skipping restores dystrophin expression in vitro in a canine model of DMD},
  author={Graham Mcclorey and Hong M. Moulton and Patrick L. Iversen and Susan Fletcher and Stephen D. Wilton},
  journal={Gene Therapy},
  year={2006},
  volume={13},
  pages={1373-1381}
}
Manipulation of pre-mRNA splicing by antisense oligonucleotides (AOs) offers considerable potential for a number of genetic disorders. One of these is Duchenne muscular dystrophy (DMD), where mutations in the dystrophin gene typically result in premature termination of translation that causes a loss of functional protein. AOs can induce exon skipping such that the mutation is by-passed and the reading frame restored, producing an internally deleted protein similar to that found in the milder… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
77 Extracted Citations
27 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 77 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 27 references

Similar Papers

Loading similar papers…