Antisense oligonucleotide containing an internal, non-nucleotide-based linker promote site-specific cleavage of RNA.

@article{Reynolds1996AntisenseOC,
  title={Antisense oligonucleotide containing an internal, non-nucleotide-based linker promote site-specific cleavage of RNA.},
  author={Mark Alexander Reynolds and Tobias Beck and Phillip Say and David A. Schwartz and Brian P. Dwyer and William J R Daily and Morteza M Vaghefi and Michael D Metzler and Robert E Klem and Lyle J. Arnold},
  journal={Nucleic acids research},
  year={1996},
  volume={24 4},
  pages={760-65}
}
We have designed and synthesized a series of novel antisense methylphosphonate oligonucleotide (MPO) cleaving agents that promote site-specific cleavage on a complementary RNA target. These MPOs contain a non- nucleotide-based linking moiety near the middle of the sequence in place of one of the nucleotide bases. The region surrounding the unpaired base on… CONTINUE READING