Antisense oligodeoxynucleotides to opioid mu and delta receptors reduced morphine dependence in mice: role of delta-2 opioid receptors.

@article{SnchezBlzquez1997AntisenseOT,
  title={Antisense oligodeoxynucleotides to opioid mu and delta receptors reduced morphine dependence in mice: role of delta-2 opioid receptors.},
  author={Pilar S{\'a}nchez-Bl{\'a}zquez and Antonio Garc{\'i}a-Espa{\~n}a and J. Rodŕıguez Garz{\'o}n},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={280 3},
  pages={1423-31}
}
Repeated intracerebroventricular injections of antisense oligodeoxynucleotides (ODNs) were used to selectively restrict the expression of cloned mu and delta opioid receptors (OR) in the mouse brain. Reduction of mu and delta OR-like immunoreactivity was observed in brain structures of experimental mice. A random-sequence ODN used as a control showed no effect. ODNs to OR decreased radiolabeling of neural structures after intracerebroventricular injection of 125I-immunoglobulins G directed to… CONTINUE READING