Antisense oligodeoxynucleotide to inducible nitric oxide synthase inhibits nitric oxide synthesis in rat pulmonary artery smooth muscle cells in culture.

Abstract

BACKGROUND We recently demonstrated the induced expression of the inducible nitric oxide synthase (iNOS) gene in cultured rat pulmonary artery smooth muscle (RPASM) in response to lipopolysaccharide and cytokines, using a complementary DNA probe to murine macrophage iNOS. Because nitric oxide (NO) can be cytotoxic, iNOS in the pulmonary vasculature may… (More)

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@article{Thomae1993AntisenseOT, title={Antisense oligodeoxynucleotide to inducible nitric oxide synthase inhibits nitric oxide synthesis in rat pulmonary artery smooth muscle cells in culture.}, author={K. R. Thomae and D. Geller and Timothy R Billiar and P. Davies and Bertrand Pitt and Reid Simmons and Don K. Nakayama}, journal={Surgery}, year={1993}, volume={114 2}, pages={272-7} }