Antisense oligodeoxynucleotide to inducible nitric oxide synthase protects against transient focal cerebral ischemia-induced brain injury.

@article{ParmentierBatteur2001AntisenseOT,
  title={Antisense oligodeoxynucleotide to inducible nitric oxide synthase protects against transient focal cerebral ischemia-induced brain injury.},
  author={S Parmentier-Batteur and Georg Andrees Bohme and Dominique Lerouet and L Zhou-Ding and V Beray and Isabelle Margaill and Michel Plotkine},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2001},
  volume={21 1},
  pages={15-21}
}
Nitric oxide (NO) has been suspected to mediate brain damage during ischemia. Here the authors studied the effects of an antisense oligodeoxynucleotide (ODN) directed against the inducible isoform of NO synthase (iNOS) in a model of transient focal cerebral ischemia in rats. Treatment consisted of seven intracerebroventricular injections of a phosphodiester… CONTINUE READING