Antisense-mediated exon skipping to correct IL-12 R β 1 deficiency in T cells

@inproceedings{Vosse2009AntisensemediatedES,
  title={Antisense-mediated exon skipping to correct IL-12 R β 1 deficiency in T cells},
  author={Esther van de Vosse and Els M. Verhard and Roelof A. de Paus and Jaap T. van Dissel},
  year={2009}
}
Patients with Mendelian susceptibility to mycobacterial disease have severe, recurrent life-threatening infections with otherwise poorly pathogenic mycobacteria and salmonellae. The extreme susceptibility is the result of genetic defects in the interleukin-12/interferon(IL-12/IFN) pathway. The infections are difficult to treat, and therapeutic options are… CONTINUE READING