Antisense lncRNA LDLRAD4-AS1 promotes metastasis by decreasing the expression of LDLRAD4 and predicts a poor prognosis in colorectal cancer

@article{Mo2020AntisenseLL,
  title={Antisense lncRNA LDLRAD4-AS1 promotes metastasis by decreasing the expression of LDLRAD4 and predicts a poor prognosis in colorectal cancer},
  author={S. Mo and Long Zhang and W. Dai and Lingyu Han and Ren-jie Wang and Wenqiang Xiang and Zhimin Wang and Qingguo Li and J. Yu and J. Yuan and S. Cai and G. Cai},
  journal={Cell Death \& Disease},
  year={2020},
  volume={11}
}
Long noncoding RNAs (lncRNAs) have been revealed to play critical roles in tumor initiation and progression. The antisense lncRNA LDLRAD4-AS1 is the longest lncRNA of LDLRAD4, and its expression levels, cellular localization, precise function, and mechanism in colorectal cancer (CRC) remain unknown. In this study, we observed that lncRNA LDLRAD4-AS1 was located in the nucleus of CRC cells and that lncRNA LDLRAD4-AS1 was upregulated in most CRC specimens and cell lines. Overexpression of lncRNA… Expand
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  • Xiang-jun Chen, Sha Liu, +5 authors Li Yu
  • Medicine
  • Frontiers in Oncology
  • 2020
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