Antisense inhibition of neuronal nicotinic receptors in the tobacco-feeding insect, Manduca sexta.

@article{Fickbohm2003AntisenseIO,
  title={Antisense inhibition of neuronal nicotinic receptors in the tobacco-feeding insect, Manduca sexta.},
  author={David Fickbohm and Barry A. Trimmer},
  journal={Archives of insect biochemistry and physiology},
  year={2003},
  volume={53 4},
  pages={172-85}
}
Acetylcholine is the predominant excitatory transmitter in the insect central nervous system with many of its effects mediated by nicotinic acetylcholine receptors. These receptors are present at very high density and are structurally heterogeneous, although little is known about functional distinctions between them. An interesting system for examining these receptors is the larval stage of Manduca sexta, a nicotine-resistant tobacco-feeding insect. The nicotinic responses of cultured neurons… CONTINUE READING