Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease.

@article{Choi2001AntisenseIO,
  title={Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease.},
  author={Sun Jin Choi and Yasuo Oba and Y Gazitt and M. Sabes Alsina and Juliana C Cruz and Judith L. Anderson and Garson David Roodman},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={108 12},
  pages={1833-41}
}
We recently identified macrophage inflammatory protein 1-alpha (MIP-1alpha) as a factor produced by multiple myeloma (MM) cells that may be responsible for the bone destruction in MM (1). To investigate the role of MIP-1alpha in MM bone disease in vivo, the human MM-derived cell line ARH was stably transfected with an antisense construct to MIP-1alpha (AS-ARH) and tested for its capacity to induce MM bone disease in SCID mice. Human MIP-1alpha levels in marrow plasma from AS-ARH mice were… CONTINUE READING

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