Antisense inhibition of epidermal growth factor receptor decreases expression of human surfactant protein A.

@article{Klein2000AntisenseIO,
  title={Antisense inhibition of epidermal growth factor receptor decreases expression of human surfactant protein A.},
  author={Jonathan M. Klein and Troy A. McCarthy and John M. Dagle and Jeanne M. Snyder},
  journal={American journal of respiratory cell and molecular biology},
  year={2000},
  volume={22 6},
  pages={676-84}
}
Epidermal growth factor (EGF) stimulates surfactant protein A (SP-A) synthesis in fetal lung tissue through ligand binding to the EGF receptor. We hypothesized that inhibition of EGF receptor messenger RNA (mRNA) would block SP-A expression in human fetal lung tissue during alveolar type II cell differentiation in vitro. Midtrimester human fetal lung explants were maintained in serum-free Waymouth's medium for 3 to 5 d in the presence or absence of an antisense 18-mer phosphorothioate… CONTINUE READING
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