Antisense inhibition of Na+/Ca2+ exchange during anoxia/reoxygenation in ventricular myocytes.

@article{Eigel2001AntisenseIO,
  title={Antisense inhibition of Na+/Ca2+ exchange during anoxia/reoxygenation in ventricular myocytes.},
  author={B N Eigel and Robert W. Hadley},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={281 5},
  pages={
          H2184-90
        }
}
This study investigated the role of the Na+/Ca2+ exchanger (NCX) in regulating cytosolic intracellular Ca2+ concentration ([Ca2+]i) during anoxia/reoxygenation in guinea pig ventricular myocytes. The hypothesis that the NCX is the predominant mechanism mediating [Ca2+]i overload in this model was tested through inhibition of NCX expression by an antisense oligonucleotide. Immunocytochemistry revealed that this antisense oligonucleotide, directed at the area around the start site of the guinea… CONTINUE READING
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Antisense inhibition of the cardiac Na1/Ca21 exchanger suppresses cytosolic [Ca21] accumulation during anoxia/reoxygenation in cultured adult guinea pig ventricular myocytes (Abstract)

BN Eigel, RW Hadley
Circulation 102: II136–II137, • 2000
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