Antisense inhibition of IGF receptor expression in HaCaT keratinocytes: a model for antisense strategies in keratinocytes.

@article{White2000AntisenseIO,
  title={Antisense inhibition of IGF receptor expression in HaCaT keratinocytes: a model for antisense strategies in keratinocytes.},
  author={Paul White and Rhys D. Fogarty and George Arthur Werther and Christopher J. Wraight},
  journal={Antisense & nucleic acid drug development},
  year={2000},
  volume={10 3},
  pages={195-203}
}
Antisense strategies targeting skin conditions are attractive in concept, with a number of possible pathologic conditions, such a psoriasis, apparently suitable for such an approach. Because in vitro screening of candidate sequences is usually desirable, we have attempted to use a range of new generation cationic lipids to produce significant antisense oligodeoxynucleotide (ODN) uptake in an immortalized keratinocyte cell line (HaCaT). A large number of commercially available lipids were… CONTINUE READING