Antisense inhibition of CD44 tailless splice variant in human articular chondrocytes promotes hyaluronan internalization.

@article{Jiang2001AntisenseIO,
  title={Antisense inhibition of CD44 tailless splice variant in human articular chondrocytes promotes hyaluronan internalization.},
  author={Hongbin Jiang and Cheryl B. Knudson and Warren Knudson},
  journal={Arthritis and rheumatism},
  year={2001},
  volume={44 11},
  pages={2599-610}
}
OBJECTIVE To determine whether alternatively spliced variants of CD44, in particular a short, intracellular tail CD44 isoform, are used by articular chondrocytes to modulate the functions of this matrix receptor. METHODS Normal human articular chondrocytes were cultured with or without interleukin-1alpha (IL-1alpha), and the relative expression of CD44 exon 19 and CD44 exon 20, hyaluronan synthase 2, aggrecan, and GAPDH messenger RNA (mRNA) was determined using reverse transcriptase… CONTINUE READING

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