Antisense fosB RNA inhibits thrombin-induced hypertrophy in cultured pulmonary arterial smooth muscle cells.

@article{Lu1998AntisenseFR,
  title={Antisense fosB RNA inhibits thrombin-induced hypertrophy in cultured pulmonary arterial smooth muscle cells.},
  author={Cao Lu and Frank J. Giordano and Xuping Bao and Kristin D Morris and Abraham Rothman},
  journal={Circulation},
  year={1998},
  volume={98 6},
  pages={
          596-603
        }
}
BACKGROUND We have previously reported that fosB mRNA is induced by hypertrophic stimuli (thrombin, angiotensin II) but not proliferative stimuli (platelet-derived growth factor, basic fibroblast growth factor) in pulmonary arterial smooth muscle cells (PASMCs) (J Biol Chem. 1994;9:6399-6404). Our aim in the present study was to investigate the potential role of FosB in PASMC hypertrophy. METHODS AND RESULTS Adenoviruses carrying sense or antisense fosB RNA expression cassettes were used to… CONTINUE READING

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