Antisense expression of protein kinase C alpha inhibits the growth and tumorigenicity of human glioblastoma cells.

@article{Ahmad1994AntisenseEO,
  title={Antisense expression of protein kinase C alpha inhibits the growth and tumorigenicity of human glioblastoma cells.},
  author={Sumera R Ahmad and Toshihiro Mineta and Robert L. Martuza and Robert I Glazer},
  journal={Neurosurgery},
  year={1994},
  volume={35 5},
  pages={904-8; discussion 908-9}
}
To investigate the role of protein kinase C (PKC) in the growth of astrocytic brain tumors, human glioblastoma cell line U-87 was stably transfected with the antisense complementary deoxyribonucleic acid encoding PKC alpha. The effect of selectively down-regulating the alpha isoform on other PKC isoforms, as well as serum-dependent proliferation and in vivo tumorigenicity, was determined. U-87 cells expressed high levels of PKC alpha and lesser amounts of the gamma, epsilon, and zeta isoforms… CONTINUE READING

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