Antisense drug discovery and development.

  title={Antisense drug discovery and development.},
  author={Tsuyoshi Yamamoto and Moeka Nakatani and Keisuke Narukawa and Satoshi Obika},
  journal={Future medicinal chemistry},
  volume={3 3},
Numerous chemically modified oligonucleotides have been developed so far and show their own unique chemical properties and pharmacodynamic/pharmacokinetic characteristics. Among all non-natural nucleotides, to the best of our knowledge, only five chemistries are currently being tested in clinical trials: phosphorothioate, 2´-O-methyl RNA, 2´-O-methoxyethyl RNA, 2´,4´-bridged nucleic acid/locked nucleic acid and the phosphorodiamidate morpholino oligomer. Since phosphorothioate modification can… CONTINUE READING


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Bridged nucleic acids: development, synthesis and properties

  • S Obika, SMA Rahman, A Fujisaka
  • Heterocycles 81,
  • 2010

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