Antisense down-regulation of metallothionein induces growth arrest and apoptosis in human breast carcinoma cells.

@article{AbdelMageed1997AntisenseDO,
  title={Antisense down-regulation of metallothionein induces growth arrest and apoptosis in human breast carcinoma cells.},
  author={Asim B. Abdel-Mageed and Krishna C. Agrawal},
  journal={Cancer gene therapy},
  year={1997},
  volume={4 3},
  pages={199-207}
}
The association of increased metallothionein (MT) gene expression in breast cancer with metastasis and poor prognosis has led us to investigate the hypothesis that inhibition of MT gene expression may elicit antiproliferative effects in breast carcinoma MCF7 cells. To monitor the effect of downregulation of MT protein on growth, MCF7 cells were transiently transfected by electroporation with an 18-mer MT antisense phosphorothioate oligomer (AO) or an 18-mer random oligomer (RO). The MT-AO is… CONTINUE READING
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