Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice.

@article{Poon2004AntisenseDA,
  title={Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice.},
  author={Hung Fai Poon and Gururaj Joshi and Rukhsana Sultana and Susan A. Farr and W. A. Banks and J Eileen Morley and Vittorio Calabrese and David Butterfield},
  journal={Brain research},
  year={2004},
  volume={1018 1},
  pages={86-96}
}
Amyloid beta-peptide (Abeta) is known to induce free radical-mediated oxidative stress in the brain. Free radical-mediated damage to the neuronal membrane components has been implicated in the etiology of Alzheimer's disease (AD). Abeta is produced by proteolytic processing of the amyloid precursor protein (APP). The senescence accelerated mouse prone 8 (SAMP8) strain was developed by phenotypic selection from a common genetic pool. The SAMP8 strain exhibits age-related deterioration in memory… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 65 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 127 references

Protein oxidation processes in aging brain

  • D. A. Butterfield, E. R. Stadtman
  • Adv. Cell Aging Gerontol. 2
  • 1997
Highly Influential
9 Excerpts

M

  • K. Hensley, N. Hall, R. Subramaniam, P. Cole, M. Harris, M. Aksenov
  • Aksenova, S.P. Gabbita, J.F. Wu, J.M. Carney, et…
  • 1995
Highly Influential
6 Excerpts

F

  • K. J. Barnham, G. D. Ciccotosto, +8 authors I. Volitakis
  • Separovic, C.J. Barrow, J.D. Wade, C.L. Masters…
  • 2003
2 Excerpts

Similar Papers

Loading similar papers…