Antisense Transcription in the Mammalian Transcriptome

@article{Katayama2005AntisenseTI,
  title={Antisense Transcription in the Mammalian Transcriptome},
  author={Shintaro Katayama and Yasuhiro Tomaru and Takeya Kasukawa and Kazunori Waki and Misato Nakanishi and M Nakamura and Hiromi Nishida and Chan Choo Yap and M. Suzuki and Jun Kawai and H. Suzuki and Piero Carninci and Yoshihide Hayashizaki and Christine A. Wells and Martin C. Frith and Timothy Ravasi and Ken C. Pang and Jennifer S. Hallinan and John S. A. Mattick and David A. Hume and Leonard Lipovich and Sergei Batalov and P{\"a}r G. Engstr{\"o}m and Y Mizuno and Mohammad Ali Faghihi and Albin Sandelin and Alistair M. Chalk and Salim Mottagui-Tabar and Zhang Liang and Boris Lenhard and Claes Wahlestedt},
  journal={Science},
  year={2005},
  volume={309},
  pages={1564 - 1566}
}
Antisense transcription (transcription from the opposite strand to a protein-coding or sense strand) has been ascribed roles in gene regulation involving degradation of the corresponding sense transcripts (RNA interference), as well as gene silencing at the chromatin level. Global transcriptome analysis provides evidence that a large proportion of the genome can produce transcripts from both strands, and that antisense transcripts commonly link neighboring “genes” in complex loci into chains of… 
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TLDR
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TLDR
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TLDR
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[Natural antisense transcript and its mechanism of gene regulation].
TLDR
It is speculated that both of sense and antisense transcripts may be sliced to form small RNAs, which is also an important mechanism for NATs to regulate gene expression, such as rasiRNAs in "ping-pong".
cis-Antisense RNA and Transcriptional Interference: Coupled Layers of Gene
TLDR
This work has shown that a combination of transcriptional interference and cis-antisense RNA interaction has the potential to add multiple-levels of regulation which can allow such a system to have a tunable and complex higher-order system response to environmental stimuli.
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