Antisense Pharmacodynamics: Critical Issues in the Transport and Delivery of Antisense Oligonucleotides

@article{Juliano1999AntisensePC,
  title={Antisense Pharmacodynamics: Critical Issues in the Transport and Delivery of Antisense Oligonucleotides},
  author={Rudolph L Juliano and Suresh K Alahari and Hoon Sik Yoo and R. Kole and Moo Je Cho},
  journal={Pharmaceutical Research},
  year={1999},
  volume={16},
  pages={494-502}
}
This review critically examines current understanding of the kinetics and biodistribution of antisense oligonucleotides, both at the cellular level and at the level of the intact organism. The pharmacodynamic relationships between biodistribution and the ultimate biological effects of antisense agents are considered. The problems and advantages inherent in the use of delivery systems are discussed in the light of further enhancing in vivo pharmacological actions of oligonucleotides. 

From This Paper

Topics from this paper.
40 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

Similar Papers

Loading similar papers…