Antisense Oligonucleotides Targeting Influenza A Segment 8 Genomic RNA Inhibit Viral Replication

@inproceedings{Lenartowicz2016AntisenseOT,
  title={Antisense Oligonucleotides Targeting Influenza A Segment 8 Genomic RNA Inhibit Viral Replication},
  author={Elżbieta Lenartowicz and Aitor Nogales and Elzbieta Kierzek and Ryszard Kierzek and Luis Mart{\'i}nez-Sobrido and Douglas H. Turner},
  booktitle={Nucleic acid therapeutics},
  year={2016}
}
Influenza A virus (IAV) affects 5%-10% of the world's population every year. Through genome changes, many IAV strains develop resistance to currently available anti-influenza therapeutics. Therefore, there is an urgent need to find new targets for therapeutics against this important human respiratory pathogen. In this study, 2'-O-methyl and locked nucleic acid antisense oligonucleotides (ASOs) were designed to target internal regions of influenza A/California/04/2009 (H1N1) genomic viral RNA… CONTINUE READING
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