Antisense Oligonucleotides, A Novel Developing Targeting Therapy

@inproceedings{Karaki2019AntisenseOA,
  title={Antisense Oligonucleotides, A Novel Developing Targeting Therapy},
  author={Sara Karaki and Cl{\'e}ment Paris and Palma Rocchi},
  year={2019}
}
Antisense oligonucleotides (ASOs) have been validated as therapeutic agents and an important tool in molecular biology. Indeed, ASOs are used either in vitro or in vivo to generate mRNA selective knockouts. They can be used for human therapy since ASOs can inhibit specifically target genes especially whose are difficult to target with small molecules inhibitors or neutralizing antibodies. However, despite their specificity and broadness of use, some practical obstacles remain unsolved in… CONTINUE READING

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