Antisense Knockdown of the Shaker-like Kv1.1 Gene Abolishes the Central Stimulatory Effects of Amphetamines in Mice and Rats

@article{Ghelardini2003AntisenseKO,
  title={Antisense Knockdown of the Shaker-like Kv1.1 Gene Abolishes the Central Stimulatory Effects of Amphetamines in Mice and Rats},
  author={Carla Ghelardini and Alessandro Quattrone and Nicoletta Galeotti and Silvia Livi and Grazia Banchelli and Laura Raimondi and Renato Pirisino},
  journal={Neuropsychopharmacology},
  year={2003},
  volume={28},
  pages={1096-1105}
}
Amphetamine (AMPH) is an indirect sympathomimetic compound classified as a substrate-type releaser that distinguishes it from other stimulants that act as uptake 1 blockers, such as cocaine (COC). In mammals, AMPH elicits central stimulation, hypermotility, anorexia, analgesia and analeptic activity, mainly through the increase of extracellular brain dopamine (DA). The inversion of vesicular transporters and/or intravesicular alkalinization is assumed to have a role in AMPH-induced exocytosis… CONTINUE READING