Antisense DNAs as multisite genomic modulators identified by DNA microarray.

  title={Antisense DNAs as multisite genomic modulators identified by DNA microarray.},
  author={Yee Sook Cho and Mickey K. Kim and Christopher Cheadle and Catherine Neary and Kevin G. Becker and Y S Cho-chung},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={98 17},
Antisense oligodeoxynucleotides can selectively block disease-causing genes, and cancer genes have been chosen as potential targets for antisense drugs to treat cancer. However, nonspecific side effects have clouded the true antisense mechanism of action and hampered clinical development of antisense therapeutics. Using DNA microarrays, we have conducted a systematic characterization of gene expression in cells exposed to antisense, either exogenously or endogenously. Here, we show that in a… CONTINUE READING