Antisense DNA Inhibition of Tumor Growth Induced by c-Ha-ras Oncogene in Nude Mice1

Abstract

Antisense DNA has shown an ability to target specific oncogene tran scripts and inhibit their expression in cells, but the degree to which sus tained treatment can suppress total levels of an oncogenic product and alter tumorigenesis in vivo remains to be determined. In this study, NIH3T3 cells transformed by the activated c-Ha-ras oncogene from T24 hu man… (More)

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