Antiseizure and neurotoxic effects of various combinations of phenobarbital, diazepam, sodium valproate and 1,4-dihydropyridine riodipin


The use of different anticonvulsants as 2-, 3-, or 4-member combinations considerably potentiates their antiseizure effects and, though to a lesser degree, increases their neurotoxicity. In most of these combinations the therapeutic index is considerably higher than in the case of individual preparations. 
DOI: 10.1007/BF02444358


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