Antiseizure Activity of Midazolam in Mice Lacking δ-Subunit Extrasynaptic GABA(A) Receptors.

@article{Reddy2015AntiseizureAO,
  title={Antiseizure Activity of Midazolam in Mice Lacking δ-Subunit Extrasynaptic GABA(A) Receptors.},
  author={Sandesh D. Reddy and Iyan Younus and Bryan L. Clossen and Doodipala Samba Reddy},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2015},
  volume={353 3},
  pages={
          517-28
        }
}
Midazolam is a benzodiazepine anticonvulsant with rapid onset and short duration of action. Midazolam is the current drug of choice for acute seizures and status epilepticus, including those caused by organophosphate nerve agents. The antiseizure activity of midazolam is thought to result from its allosteric potentiation of synaptic GABA(A) receptors in the brain. However, there are indications that benzodiazepines promote neurosteroid synthesis via the 18-kDa cholesterol transporter protein… CONTINUE READING
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