Corpus ID: 2906785

Antisecretory effects of two new histamine H2-receptor antagonists.

@article{Bickel1986AntisecretoryEO,
  title={Antisecretory effects of two new histamine H2-receptor antagonists.},
  author={M. Bickel and A. Herling and T. J. Rising and K. Wirth},
  journal={Arzneimittel-Forschung},
  year={1986},
  volume={36 9},
  pages={
          1358-63
        }
}
N-(3-[3-(1-Piperidinylmethyl)phenoxy]propyl)acetoxyaceta mide hydrochloride (Hoe 760) and N-(3-[3-(1-piperidinylmethyl)phenoxy]propyl)glycolamine hydrochloride (Hoe 062) are highly specific H2-receptor antagonists. The compounds are equipotent after intragastrical or intravenous administration. The antagonists inhibited gastric acid secretion in the rat induced by all stimuli tested, carbachol, desglugastrin and histamine. In the Heidenhain pouch dog whose gastric acid secretion was stimulated… Expand
13 Citations
Action of pentacaine on gastric acid secretion
Chemical and biologic characteristics of roxatidine acetate.
A Review of the Animal Pharmacology of Roxatidine Acetate
Roxatidine Acetate
...
1
2
...