Antischistosomal activities of mefloquine-related arylmethanols.

@article{Ingram2012AntischistosomalAO,
  title={Antischistosomal activities of mefloquine-related arylmethanols.},
  author={Katrin J Ingram and William James Ellis and Jennifer Keiser},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 6},
  pages={3207-15}
}
Interesting antischistosomal properties have been documented for the antimalarial mefloquine, a 4-quinolinemethanol. We evaluated the antischistosomal activities of nine mefloquine-related compounds belonging to the 4-pyridinemethanols, 9-phenanthrenmethanols, and 4-quinolinemethanols. Eight compounds revealed high activities against Schistosoma mansoni in vitro, with two drugs (the 4-quinolinemethanols WR7573 and WR7930) characterized by significantly lower half-maximal inhibitory… CONTINUE READING

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Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, and praziquantel against Schistosoma haematobium: randomized, exploratory open-label trial

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