Antischistosomal activities of mefloquine-related arylmethanols.

  title={Antischistosomal activities of mefloquine-related arylmethanols.},
  author={Katrin J Ingram and William James Ellis and Jennifer Keiser},
  journal={Antimicrobial agents and chemotherapy},
  volume={56 6},
Interesting antischistosomal properties have been documented for the antimalarial mefloquine, a 4-quinolinemethanol. We evaluated the antischistosomal activities of nine mefloquine-related compounds belonging to the 4-pyridinemethanols, 9-phenanthrenmethanols, and 4-quinolinemethanols. Eight compounds revealed high activities against Schistosoma mansoni in vitro, with two drugs (the 4-quinolinemethanols WR7573 and WR7930) characterized by significantly lower half-maximal inhibitory… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 22 extracted citations


Publications referenced by this paper.
Showing 1-10 of 35 references

Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, and praziquantel against Schistosoma haematobium: randomized, exploratory open-label trial

  • J Keiser
  • Clin. Infect
  • 2010
1 Excerpt

Similar Papers

Loading similar papers…