Antirheumatic gold compounds and penicillamine enhance protein kinase C‐mediated activation of the arachidonate‐ mobilizing phospholipase A2 in mouse macrophages

@article{Bondeson1993AntirheumaticGC,
  title={Antirheumatic gold compounds and penicillamine enhance protein kinase C‐mediated activation of the arachidonate‐ mobilizing phospholipase A2 in mouse macrophages},
  author={J. Bondeson and R. Sundler},
  journal={Journal of Leukocyte Biology},
  year={1993},
  volume={54}
}
  • J. Bondeson, R. Sundler
  • Published 1993
  • Biology, Medicine
  • Journal of Leukocyte Biology
  • The effects of antirheumatic gold compounds and D‐penicillamine on protein kinase C‐ and Ca2+‐ mediated activation of arachidonate mobilization and the formation of eicosanoids in mouse macrophages have been investigated. Auranofin (0.2‐2 μΜ) enhanced the response to phorbol ester two‐ to three‐fold, and similar enhancement was caused by aurothiomalate, aurothioglu‐ cose, and penicillamine, but only after pretreatment for 1‐4 h. The enhanced mobilization of arachidonate was accompanied by… CONTINUE READING
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