Antiretroviral treatment interruptions predict female genital shedding of genotypically resistant HIV-1 RNA.

@article{Graham2012AntiretroviralTI,
  title={Antiretroviral treatment interruptions predict female genital shedding of genotypically resistant HIV-1 RNA.},
  author={Susan Marie Graham and Zahra Jalalian-Lechak and Juma Shafi and Vrasha Chohan and Ruth W. Deya and Walter G. Jaoko and Kishorchandra N. Mandaliya and Norbert Peshu and Julie M Overbaugh and R Scott McClelland},
  journal={Journal of acquired immune deficiency syndromes},
  year={2012},
  volume={60 5},
  pages={511-8}
}
OBJECTIVES Resistant viruses may emerge in the female genital tract during antiretroviral therapy (ART). Our objective was to identify predictors of drug-resistant HIV-1 RNA in genital secretions after initiation of nonnucleoside reverse transcriptase inhibitor-based therapy. DESIGN We conducted a prospective cohort study with periodic evaluation of plasma and genital swab samples for HIV-1 RNA levels and antiretroviral resistance mutations. METHODS First-line ART was initiated in 102 women… CONTINUE READING
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