Antiretroviral therapy promotes an inflammatory-like pattern of human T-cell lymphotropic virus type 1 (HTLV-1) replication in human immunodeficiency virus type 1/HTLV-1 co-infected individuals.

Abstract

Upon antiretroviral therapy (ART) human immunodeficiency virus (HIV)/human T-cell lymphotropic virus type 1 (HTLV-1) co-infected individuals frequently develop neurological disorders through hitherto unknown mechanisms. Here, we show that effective anti-HIV ART increases HTLV-1 proviral load through a polyclonal integration pattern of HTLV-1 in both CD4(+) and CD8(+) T-cell subsets that is reminiscent of that typically associated with HTLV-1-related inflammatory conditions. These data indicate that preventing ART-triggered clonal expansion of HTLV-1-infected cells in co-infected individuals deserves investigation.

DOI: 10.1099/vir.0.048348-0

Cite this paper

@article{Pomier2013AntiretroviralTP, title={Antiretroviral therapy promotes an inflammatory-like pattern of human T-cell lymphotropic virus type 1 (HTLV-1) replication in human immunodeficiency virus type 1/HTLV-1 co-infected individuals.}, author={Carole Pomier and Samira Rabaaoui and J Pouliquen and Pierre Couppi{\'e} and Myriam El Guedj and Mathieu Nacher and Vincent Lacoste and E Wattel and Mirdad Kazanji and Franck Mortreux}, journal={The Journal of general virology}, year={2013}, volume={94 Pt 4}, pages={753-7} }